How do you block spam that always comes from a different sender?

Vanise: How do you block spam that always comes from a different sender?
I mark messages as spam, but they always appear to come from a different sender so it’s impossible to keep them blocked.

Answers and Views:

Answer by Larry W
block on the subject content or text content. I send anything that has “nigerian” “prescription” etc directly to the trash folder.

Answer by Holness_202
person above me has a good answer
failing that if you use outlook ie not web mail you can get most anti virus things to filter ur email for you.

Answer by dragonfire
are you web based email?
good luck then
as they blocking and filtering are weak
you are better off going non web based email and using thunderbird
as thunderbird learns what is spam and act accordingly
you should also have a junk account and a good account
the junk is used for “verification” or registering at various websites that require it, so you do not care if it gets spammed, you also supply false information on the junk account, you NEVEr use your real names etc…your ISP will have a master account that you use for meail, all ISP let you creat sub accounts, NEVER use the master account for legit email ( banking, credit card, etc.. ) always use a sub account since if it gets spammed or compromise, you can create a new one and delete the sub account, changing a master account is a real pain, and filtering is much easier with a non web based account